Exploring the therapeutic potential of microneedle radiofrequency treatment for cluster headache: A double-blind, randomized controlled crossover pilot study.

To date, there is no effective treatment to stop episodes (or clusters) in cluster headache (CH). Patients enduring these clusters routinely take high doses of abortive treatments (such as triptans) and disease-modifying treatments (including Ca++ antagonists and cortisone), with profound implications for their quality of life. This pilot study aims to assess the efficacy and safety of microneedle radiofrequency treatment as a promising approach for CH. Given the prevalent hypersensitive skin (e.g., cutaneous allodynia) observed in CH, our study focusses on somatosensory changes as a prospective therapeutic target. Utilizing a randomized controlled trial framework in cross-over, this pilot study will assess pain relief, the frequency of headache episodes, and potential side effects in patients. Anticipated outcomes include significant pain reduction and a low incidence of adverse effects. The study's findings will shape future, broader research. The overarching goal remains to address the pressing need for more effective and safer therapeutic alternatives for those affected by CH.

• Opsommer Emmanuelle, Professeur ordinaire, HESAV
• Melo Pereira Anibal Manuel, Collaborateur Ra&D, HESAV
• Korogod Natalya, Adjointe scientifique, HESAV

• HES-SO - Haute école spécialisée de Suisse occidentale - Rectorat
• La Source